Uterine Fibroids in Adolescence: Understanding and Addressing Early Onset


Uterine fibroids, also known as leiomyomas, are common neoplasms of the uterus, presenting a significant health concern for women worldwide.1 

These non-cancerous growths often appear during childbearing years, leading to a myriad of symptoms. These symptoms could range from mild to more severe which affects the quality of daily life and could impact the reproductive outcomes of women across the globe. Most fibroids are not symptomatic, and many women are not aware they have them. 


Prevalence and Incidence Trends 

constant. This reflects more complex interactions between genetics, the environment, and socio-demographic factors. From 1990 to 2019, the number of incident cases globally increased significantly, underscoring the growing burden of this condition on women’s health services. 2 

Of special interest is that this trend is not uniform. For example, high middle socio-demographic index regions have experienced a decline in age-standardized incidence rate, whereas low-middle socio-demographic index regions have witnessed a remarkable growth after 2005. 2 

Such vast discrepancies highlight the influence of socio-economic factors and healthcare access when treating and managing uterine fibroids. 

Global Burden and Regional Variations 

The global burden of uterine fibroids is immense 2, with millions of women affected worldwide. The incident cases of uterine fibroids increased from 5,7 million incidences in 1990 to 9,6 million incidences in 2017. 3 

Of special interest is that while the incidence rate increased, the age-standardized decreased incidence and disability-adjusted life years (DALYs) rates displayed varied trends across different regions, reflecting discrepancies in healthcare systems, diagnostic capabilities, and awareness.  

 In Europe, particularly in Eastern Europe, countries like Ukraine, Russia, and the Republic of Moldova reported the highest age standardized rate in 2019. 3 Regions with relatively high socio-demographic index regions, including Australasia and Central Europe, have seen a downward trend in age-standardized incidence rate. This shows a definite upward trend in effective management strategies or differential exposure to risk factors. 

Management and Future Directions 

The management of uterine fibroids is multifaceted and involves a range of options from watchful waiting to advanced surgical interventions. Treatment decisions are usually influenced by the severity of symptoms, size of fibroids, and location. It is also influenced by the patient’s reproductive desires. Recent advancements in both surgical and non-surgical treatments 4 have significantly improved the quality of life for thousands of women suffering from uterine fibroids. 


Uterine fibroids represent a significant global health issue, impacting on women’s health, fertility, and overall quality of life. While the incidence and prevalence of fibroids continue to escalate in some regions, great strides in treatment and the management of fibroids offer hope for millions of sufferers. 

Trends across the treatment of SDIs underline the importance of tailored healthcare policies and access to advanced medical care to effectively address the problem. 

 In conclusion, uterine leiomyomas, or uterine fibroids are some of the most common yet misunderstood diseases in women. 4 

What is the number one uterine fibroid care plan moving forward? 

Understanding uterine fibroids calls for a more comprehensive approach that addresses the intricate interplay of genetic, environmental, and socio-demographic factors. As research continues to evolve, so will strategic management for managing this condition. The ultimate outcome is to reduce the negative impact fibroids have on millions of women across the globe. 

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